About the Authors

Kazuki Noda

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Sota Nakajima

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Shigeo Godo

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Hiroki Saito

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Shohei Ikeda

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Toru Shimizu

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Budbazar Enkhjargal

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Yoshihiro Fukumoto

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Sohei Tsukita

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan

Tetsuya Yamada

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan

Hideki Katagiri

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan

Hiroaki Shimokawa

shimo@cardio.med.tohoku.ac.jp

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: H. Shimokawa is a consultant of Asahi Kasei Pharma Co. One of the co-authors, Yoshihiro Fukumoto is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to PLOS ONE Editorial policies and criteria.

Author Contributions

Conceived and designed the experiments: KN H. Shimokawa. Performed the experiments: SN BE SG H. Saito SI TS YF ST TY HK. Analyzed the data: KN H. Shimokawa. Contributed reagents/materials/analysis tools: KN SG H. Saito. Wrote the paper: KN H. Shimokawa.