About the Authors

Marcella K. Vaicik

Contributed equally to this work with: Marcella K. Vaicik, Jill Thyboll Kortesmaa

These authors are first authors on this work.

Affiliation Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, United States of America

Jill Thyboll Kortesmaa

Contributed equally to this work with: Marcella K. Vaicik, Jill Thyboll Kortesmaa

These authors are first authors on this work.

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Sofia Movérare-Skrtic

Affiliation Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden

Jarkko Kortesmaa

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Raija Soininen

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Göran Bergström

Affiliation Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Göteborg, Sweden

Claes Ohlsson

Affiliation Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden

Li Yen Chong

Affiliation Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore

Björn Rozell

Affiliation Clinical Research Center and Division of Pathology, Infectious Diseases, Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden

Margo Emont

Affiliation Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

Ronald N. Cohen

Affiliation Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

Eric M. Brey

brey@iit.edu

‡ These authors also contributed equally to this work and are senior authors on this work.

Affiliations Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, United States of America, Research Service, Hines Veteran Affairs Hospital, Hines, Illinois, United States of America

Karl Tryggvason

‡ These authors also contributed equally to this work and are senior authors on this work.

Affiliations Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MKV JTK SM JK RS GB CO BR RNC EMB KT. Performed the experiments: MKV JTK SM JK RS GB CO LYC BR ME. Analyzed the data: MKV JTK SM JK RS GB CO LYC BR ME RNC EMB KT. Contributed reagents/materials/analysis tools: MKV JTK SM JK RS GB CO LYC BR ME RNC EMB KT. Wrote the paper: MKV JTK RNC EMB KT.