About the Authors

Gary Mo

Affiliations Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States of America, DMPK Modeling and Simulation, Oncology, iMED, AstraZeneca, Waltham, Massachusetts, United States of America

Frank Gibbons

Affiliation DMPK Modeling and Simulation, Oncology, iMED, AstraZeneca, Waltham, Massachusetts, United States of America

Patricia Schroeder

Affiliation DMPK Modeling and Simulation, Oncology, iMED, AstraZeneca, Waltham, Massachusetts, United States of America

Wojciech Krzyzanski

wk@buffalo.edu

Affiliation Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States of America

Competing Interests

FG is currently affiliated with AstraZeneca. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FG PS. Analyzed the data: GM WK. Wrote the paper: GM FG PS WK.