About the Authors

Giuseppina T. Russo

Giuseppina.russo@unime.it

Affiliation Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

Carlo Bruno Giorda

Affiliation Metabolism and Diabetes Unit ASL TO5, Chieri, Italy

Stefania Cercone

Affiliation MSD, Rome, Italy

Antonio Nicolucci

Affiliation Department of Clinical Pharmacology and Epidemiology Fondazione Mario Negri Sud, S. Maria Imbaro, Italy

Domenico Cucinotta

Affiliation Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

on behalf of BetaDecline Study Group

Membership of the BetaDecline Study Group is provided in the Acknowledgments.

Competing Interests

One of the authors is employed by a commercial company (MSD, Rome, Italy). This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GR CBG DC. Performed the experiments: GR CBG DC. Analyzed the data: AN SC. Contributed reagents/materials/analysis tools: AN SC. Wrote the paper: GR CBG DC.