About the Authors

Kathryn L. Armour

kla22@cam.ac.uk

Affiliation Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Cheryl S. Smith

Affiliation Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Natasha C. Y. Ip

Current address: Lister Hospital, Stevenage, United Kingdom

Affiliation Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Cara J. Ellison

Current address: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

Affiliation Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Christopher M. Kirton

Current address: Wellcome Trust Sanger Institute, Cambridge, United Kingdom

Affiliation Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Anthony M. Wilkes

Affiliation Bristol Institute for Transfusion Sciences, Bristol, United Kingdom

Lorna M. Williamson

Current address: National Health Service Blood and Transplant, Watford, United Kingdom

Affiliations National Health Service Blood and Transplant, Cambridge, United Kingdom, Department of Haematology, University of Cambridge, Cambridge, United Kingdom

Michael R. Clark

Affiliation Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Competing Interests

Kathryn L. Armour, Lorna M. Williamson and Michael R. Clark have filed patent applications (‘Binding molecules derived from immunoglobulins which do not trigger complement mediated lysis’ WO 99/58572) that are owned by the University of Cambridge and cover use of the mutant IgG constant region, G1Δnab. Antibodies including G1Δnab are included in some of the assays shown. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KLA LMW MRC. Performed the experiments: KLA CSS NCYI CJE CMK AMW. Analyzed the data: KLA CSS NCYI CJE CMK AMW. Contributed reagents/materials/analysis tools: KLA CSS. Wrote the paper: KLA MRC.