About the Authors

Haiqiang Wu

Affiliation College of Life Sciences, Shenzhen University, Shenzhen, China

Fang Zhang

Affiliation College of Life Sciences, Shenzhen University, Shenzhen, China

Neil Williamson

Affiliation Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

Jie Jian

Affiliations Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom, College of Pharmacy, Guilin Medical University, Guilin, China

Liao Zhang

Affiliation College of Life Sciences, Shenzhen University, Shenzhen, China

Zeqiu Liang

Affiliation College of Life Sciences, Shenzhen University, Shenzhen, China

Jinyu Wang

Affiliation College of Life Sciences, Shenzhen University, Shenzhen, China

Linkun An

Affiliation School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, China

Alan Tunnacliffe

at10004@cam.ac.uk (AT); yzzheng@szu.edu.cn (YZ)

Affiliation Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

Yizhi Zheng

at10004@cam.ac.uk (AT); yzzheng@szu.edu.cn (YZ)

Affiliation College of Life Sciences, Shenzhen University, Shenzhen, China

Competing Interests

Work in China was supported by Shenzhen City, China (Grant No. JCYJ2012061408533365, http://www.szsti.gov.cn/, YZ). Work in Cambridge was funded by the European Research Council (Advanced Investigator Grant 233232, http://erc.europa.eu/, AT) and an anonymous donation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors′ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HW AT YZ. Performed the experiments: HW FZ NW JJ LZ ZL JW LA. Analyzed the data: HW AT YZ. Contributed reagents/materials/analysis tools: HW FZ NW LZ ZL JW. Wrote the paper: HW AT YZ. Checking: HW.