About the Authors
- Shuichi Shibuya
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Affiliation Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
- Yusuke Ozawa
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Affiliation Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
- Kenji Watanabe
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Affiliation Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
- Naotaka Izuo
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Affiliation Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
- Toshihiko Toda
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Affiliation Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
- Koutaro Yokote
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Affiliation Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
- Takahiko Shimizu
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* E-mail: shimizut@chiba-u.jp
Affiliations Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan, Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, Japan
Competing Interests
Musashino Pharmaceutical Company made a grant donation to Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, for the conduct of the animal study and for the purchase of reagents. Musashino Pharmaceutical was not involved with the scientific content of the research projects run by the Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine. The authors were not paid employees and did not receive any kind of fees from Musashino Pharmaceutical Company. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: SS TS. Performed the experiments: SS YO KW NI TT. Analyzed the data: SS TS. Wrote the paper: SS KY TS.