The Indolinone MAZ51 Induces Cell Rounding and G2/M Cell Cycle Arrest in Glioma Cells without the Inhibition of VEGFR-3 Phosphorylation: Involvement of the RhoA and Akt/GSK3β Signaling Pathways

Joo-Hee Park; Yoo-Jin Shin; Tae-Ryong Riew; Mun-Yong Lee

doi:10.1371/journal.pone.0109055

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Peer-reviewed

Research Article

The Indolinone MAZ51 Induces Cell Rounding and G2/M Cell Cycle Arrest in Glioma Cells without the Inhibition of VEGFR-3 Phosphorylation: Involvement of the RhoA and Akt/GSK3β Signaling Pathways

Joo-Hee Park,

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea
⨯
Yoo-Jin Shin,

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea
⨯
Tae-Ryong Riew,

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea
⨯
Mun-Yong Lee

* E-mail: munylee@catholic.ac.kr

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea
⨯

The Indolinone MAZ51 Induces Cell Rounding and G2/M Cell Cycle Arrest in Glioma Cells without the Inhibition of VEGFR-3 Phosphorylation: Involvement of the RhoA and Akt/GSK3β Signaling Pathways

Joo-Hee Park,
Yoo-Jin Shin,
Tae-Ryong Riew,
Mun-Yong Lee

Published: September 30, 2014
https://doi.org/10.1371/journal.pone.0109055

About the Authors

Joo-Hee Park

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea

Yoo-Jin Shin

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea

Tae-Ryong Riew

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea

Mun-Yong Lee

* E-mail: munylee@catholic.ac.kr

Affiliation Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHP MYL. Performed the experiments: JHP. Analyzed the data: JHP MYL. Contributed reagents/materials/analysis tools: YJS TRR. Contributed to the writing of the manuscript: JHP MYL.

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Glioma cells
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Cytoskeleton
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Phosphorylation
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Cell cycle and cell division
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Small interfering RNA
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Astrocytes
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Microtubules
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Immunoprecipitation
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