Impact of α-Targeted Radiation Therapy on Gene Expression in a Pre-Clinical Model for Disseminated Peritoneal Disease when Combined with Paclitaxel

Kwon Joong Yong; Diane E. Milenic; Kwamena E. Baidoo; Martin W. Brechbiel

doi:10.1371/journal.pone.0108511

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Open Access

Peer-reviewed

Research Article

Impact of α-Targeted Radiation Therapy on Gene Expression in a Pre-Clinical Model for Disseminated Peritoneal Disease when Combined with Paclitaxel

Kwon Joong Yong,

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Diane E. Milenic,

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kwamena E. Baidoo,

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Martin W. Brechbiel

* E-mail: martinwb@mail.nih.gov

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Impact of α-Targeted Radiation Therapy on Gene Expression in a Pre-Clinical Model for Disseminated Peritoneal Disease when Combined with Paclitaxel

Kwon Joong Yong,
Diane E. Milenic,
Kwamena E. Baidoo,
Martin W. Brechbiel

Published: September 30, 2014
https://doi.org/10.1371/journal.pone.0108511

About the Authors

Kwon Joong Yong

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Diane E. Milenic

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Kwamena E. Baidoo

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Martin W. Brechbiel

* E-mail: martinwb@mail.nih.gov

Affiliation Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

This research was partly supported by AREVA Med LLC. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KJY DEM KEB MWB. Performed the experiments: KJY DEM KEB. Analyzed the data: KJY. Contributed reagents/materials/analysis tools: KJY DEM KEB. Wrote the paper: KJY.

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Cancer treatment
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DNA repair
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DNA damage
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Gene expression
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Apoptosis
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Cancers and neoplasms
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Cell cycle and cell division
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