About the Authors

Michael B. Bass

mbass@amgen.com (MBB); mbass@amgen.com (SSC)

Affiliation Molecular Sciences and Computational Biology, Amgen Inc., Thousand Oaks, CA, United States of America

Bin Yao

Affiliation Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA, United States of America

Yong-Jiang Hei

Affiliation Oncology Development, Amgen Inc., Thousand Oaks, CA, United States of America

Yining Ye

Affiliation Global Biostatistical Science, Amgen Inc. South San Francisco, San Francisco, CA, United States of America

Gerard J. Davis

Affiliation Diagnostics Division Research and Development, Abbott Laboratories, Abbott Park, IL, United States of America

Michael T. Davis

Affiliation Molecular Sciences and Computational Biology, Amgen Inc., Thousand Oaks, CA, United States of America

Barbara A. Kaesdorf

Affiliation Diagnostics Division Research and Development, Abbott Laboratories, Abbott Park, IL, United States of America

Sabrina S. Chan

mbass@amgen.com (MBB); mbass@amgen.com (SSC)

Affiliation Diagnostics Division Research and Development, Abbott Laboratories, Abbott Park, IL, United States of America

Scott D. Patterson

Affiliation Medical Sciences, Amgen Inc., Thousand Oaks, CA, United States of America

Competing Interests

MBB, Y-JH, YY, MTD, and SDP are employees of and shareholders in Amgen Inc. BY was an employee of Amgen Inc. at the time this research was performed and is a shareholder in Amgen Inc. GJD and BAK are employees of and shareholders in Abbott Laboratories. SSC was an employee of Abbott Laboratories at the time this research was performed and is a shareholder in Abbott Laboratories. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MBB BY Y-JH YY GJD MTD BAK SSC SDP. Performed the experiments: MBB BY Y-JH YY GJD MTD BAK SSC SDP. Analyzed the data: MBB BY Y-JH YY GJD MTD BAK SSC SDP. Contributed reagents/materials/analysis tools: MBB BY Y-JH YY GJD MTD BAK SSC SDP. Wrote the paper: MBB BY Y-JH YY GJD MTD BAK SSC SDP.