About the Authors

Lei Ding

LD and CAG are shared first authors on this work.

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium

Conny A. Gysemans

Conny.Gysemans@med.kuleuven.be (CAG); chantal.mathieu@med.kuleuven.be (CM)

LD and CAG are shared first authors on this work.

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium

Geert Stangé

Affiliation Laboratory of Diabetes Pathology and Therapy, Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Yves Heremans

Affiliation Laboratory of Beta Cell Neogenesis (BENE), Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Yixing Yuchi

Affiliation Laboratory of Beta Cell Neogenesis (BENE), Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Tatiana Takiishi

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium

Hannelie Korf

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium

Marie Chintinne

Affiliation Laboratory of Diabetes Pathology and Therapy, Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Richard D. Carr

Affiliation MSD A/S, Ballerup, Denmark

Harry Heimberg

Affiliation Laboratory of Beta Cell Neogenesis (BENE), Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Daniel Pipeleers

Affiliation Laboratory of Diabetes Pathology and Therapy, Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Chantal Mathieu

Conny.Gysemans@med.kuleuven.be (CAG); chantal.mathieu@med.kuleuven.be (CM)

Affiliation Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O&N1, Faculty of Medicine, Katholieke Universiteit Leuven (KU LEUVEN), Leuven, Belgium

Competing Interests

Richard D. Carr owns shares in Merck Inc., (known as MSD in Europe). This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LD GS YH YY MC HK TT CAG DP CM. Performed the experiments: LD GS YH YY MC HK TT CAG. Analyzed the data: LD GS DP CAG CM. Contributed reagents/materials/analysis tools: RDC. Wrote the paper: LD YH RDC DP HH CAG CM. Revised the manuscript critically for important intellectual content: CAG CM. Guarantors of this work: LD CAG CM. Had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis: LD CAG CM.