About the Authors

Angela Deakin

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Graham Duddy

Affiliation Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Steve Wilson

Affiliation Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Steve Harrison

Affiliation Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Judi Latcham

Affiliation Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Mick Fulleylove

Affiliation Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Sylvia Fung

Affiliation Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Jason Smith

Affiliation Laboratory Animal Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Mike Pedrick

Affiliation Platform Technology and Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Tom McKevitt

Affiliation Platform Technology and Sciences, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Leigh Felton

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Joanne Morley

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Diana Quint

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Dilniya Fattah

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Brian Hayes

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Jade Gough

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Roberto Solari

roberto.2.solari@gsk.com

Current address: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College, Norfolk Place, London, United Kingdom

Affiliation Respiratory Therapy Area, GlaxoSmithKline, Stevenage, Herts, United Kingdom

Competing Interests

All studies were fully funded by GlaxoSmithKline and performed at GlaxoSmithKline, the employer of all authors at the time of the study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: AD GD LF DQ RS. Performed the experiments: AD GD SW SH JL MF SF JS MP TM LF JM DF BH JG. Analyzed the data: AD DQ RS TM SH GD LF. Contributed reagents/materials/analysis tools: AD GD SW SH JL MF SF JS MP TM LF JM BH. Wrote the paper: AD RS.