About the Authors

Niclas Franck

Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

Michael Maris

Affiliations Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Clinical and Experimental Endocrinology, Catholic University Leuven, Leuven, Belgium

Sarah Nalbandian

Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

Saswata Talukdar

Affiliation Pfizer Inc. Research Laboratories, Cambridge, Massachusetts, United States of America

Simon Schenk

Affiliation Department of Orthopedic Surgery, University of California San Diego, La Jolla, California, United States of America

Hans-Peter Hofmann

Affiliation Pfizer Inc. Research Laboratories, Cambridge, Massachusetts, United States of America

David Bullough

Affiliation Pfizer Inc. Research Laboratories, Cambridge, Massachusetts, United States of America

Olivia Osborn

oosborn@ucsd.edu

Affiliation Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

Competing Interests

Antisense oligos against IL-1Ra were a gift from Pfizer. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. Please note, that some of the authors are affiliated with Pfizer, and these authors played a role in design, data collection and preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.

Author Contributions

Conceived and designed the experiments: HH DB OO. Performed the experiments: NF SN MM. Analyzed the data: OO. Contributed reagents/materials/analysis tools: HH DB ST. Wrote the paper: OO SS.