About the Authors
- Niels H. Skotte
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Affiliation Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
- Amber L. Southwell
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Affiliation Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
- Michael E. Østergaard
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- Jeffrey B. Carroll
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Affiliation Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, Washington, United States of America
- Simon C. Warby
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Affiliation Center for Advanced Research in Sleep Medicine, Department of Psychiatry, University of Montréal, Montréal, Quebec, Canada
- Crystal N. Doty
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Affiliation Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
- Eugenia Petoukhov
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Affiliation Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
- Kuljeet Vaid
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Affiliation Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
- Holly Kordasiewicz
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- Andrew T. Watt
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- Susan M. Freier
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- Gene Hung
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- Punit P. Seth
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- C. Frank Bennett
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- Eric E. Swayze
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Affiliation ISIS Pharmaceuticals, Carlsbad, California, United States of America
- Michael R. Hayden
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* E-mail: mrh@cmmt.ubc.ca
Affiliation Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
Competing Interests
MEØ, HK, ATW, GH, SMF, PPS, CFB, and EES are employees of, with a financial interest in, Isis Pharmaceuticals. MEØ, HK, ATW, GH, SMF, PPS, CFB, and EES have an affiliation to one of the funders, ISIS Pharmaceuticals, of this research study. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: NHS ALS MEØ JBC SCW SMF GH PPS CFB EES MRH. Performed the experiments: NHS ALS CND EP KV MEO HK ATW. Analyzed the data: NHS ALS CND EP KV MEO HK ATW. Contributed reagents/materials/analysis tools: HK ATW SMF GH PPS CFB EES MRH. Contributed to the writing of the manuscript: NHS MRH. Participated in revisions: NHS ALS MEØ JBC SCW CND EP KV HK ATW SMF GH PPS CFB EES MRH.