About the Authors

Esther Conde

Affiliation Laboratorio de Dianas Terapéuticas, Centro Integral Oncológico “Clara Campal”, Hospital Universitario Madrid Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain

Ana Suárez-Gauthier

Affiliation Laboratorio de Dianas Terapéuticas, Centro Integral Oncológico “Clara Campal”, Hospital Universitario Madrid Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain

Amparo Benito

Affiliation Hospital Ramón y Cajal, Madrid, Spain

Pilar Garrido

Affiliation Hospital Ramón y Cajal, Madrid, Spain

Rosario García-Campelo

Affiliation C.H.U. A Coruña, La Coruña, Spain

Michele Biscuola

Affiliation Hospital Virgen del Rocío, Sevilla, Spain

Luis Paz-Ares

Affiliation Hospital Virgen del Rocío, Sevilla, Spain

David Hardisson

Affiliation IdiPAZ (Hospital La Paz Institute for Health Research), University Hospital La Paz, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain

Javier de Castro

Affiliation IdiPAZ (Hospital La Paz Institute for Health Research), University Hospital La Paz, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain

M. Carmen Camacho

Affiliation Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain

Delvys Rodriguez-Abreu

Affiliation Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain

Ihab Abdulkader

Affiliation C.H.U. Santiago de Compostela, Santiago de Compostela, Spain

Josep Ramirez

Affiliation Hospital Clinic, Barcelona, Spain

Noemí Reguart

Affiliation Hospital Clinic, Barcelona, Spain

Marta Salido

Affiliation Hospital del Mar-Parc de Salut Mar, Barcelona, Spain

Lara Pijuán

Affiliation Hospital del Mar-Parc de Salut Mar, Barcelona, Spain

Edurne Arriola

Affiliation Hospital del Mar-Parc de Salut Mar, Barcelona, Spain

Julián Sanz

Affiliation Hospital Clínico San Carlos, Madrid, Spain

Victoria Folgueras

Affiliation Hospital Central de Asturias, Oviedo, Spain

Noemí Villanueva

Affiliation Hospital Central de Asturias, Oviedo, Spain

Javier Gómez-Román

Affiliation Hospital Marqués de Valdecilla, Santander, Spain

Manuel Hidalgo

Affiliation Oncology Department, Centro Integral Oncológico “Clara Campal”, Hospital Universitario Madrid Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain

Fernando López-Ríos

flopezrios@hmhospitales.com

Affiliation Laboratorio de Dianas Terapéuticas, Centro Integral Oncológico “Clara Campal”, Hospital Universitario Madrid Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain

Competing Interests

E. Conde and J. Gómez-Román: honoraria, Pfizer. M. Salido: Advisory Board, Pfizer. E. Arriola: Advisory Board and Research Funding, Pfizer. F. López-Ríos: Advisory Board and Research Funding, Pfizer. Research funding: Abbott and Ventana Medical Systems. Ventana Medical Systems provided reagents free of charge. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EC FL-R. Performed the experiments: EC FL-R AS-G. Analyzed the data: EC AS-G AB PG RG-C MB LP-A DH JC MCC DR-A IA JR NR MS LP EA JS VF NV JG-R MH FL-R. Contributed reagents/materials/analysis tools: EC AS-G AB PG RG-C MB LP-A DH JC MCC DR-A IA JR NR MS LP EA JS VF NV JG-R MH FL-R. Wrote the paper: EC AS-G AB PG RG-C MB LP-A DH JC MCC DR-A IA JR NR MS LP EA JS VF NV JG-R MH FL-R.