About the Authors

Raymond N. Allan

r.allan@soton.ac.uk

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, Southampton NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom

Paul Skipp

Affiliations Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom, Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Southampton, United Kingdom

Johanna Jefferies

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, Public Health England, Southampton, United Kingdom

Stuart C. Clarke

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, Public Health England, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom

Saul N. Faust

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, Southampton NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom

Luanne Hall-Stoodley

Contributed equally to this work with: Luanne Hall-Stoodley, Jeremy Webb

Affiliations Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, Southampton NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, Microbial Infection and Immunity, Centre for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, United States of America

Jeremy Webb

Contributed equally to this work with: Luanne Hall-Stoodley, Jeremy Webb

Affiliations Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RNA PS JJ SCC SNF LHS JW. Performed the experiments: RNA. Analyzed the data: RNA LHS PS. Contributed reagents/materials/analysis tools: PS JJ SCC SNF LHS JW. Contributed to the writing of the manuscript: RNA PS JJ SCC SNF LHS JW.