Using Multi-Compartment Ensemble Modeling As an Investigative Tool of Spatially Distributed Biophysical Balances: Application to Hippocampal Oriens-Lacunosum/Moleculare (O-LM) Cells

Vladislav Sekulić; J. Josh Lawrence; Frances K. Skinner

doi:10.1371/journal.pone.0106567

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Peer-reviewed

Research Article

Using Multi-Compartment Ensemble Modeling As an Investigative Tool of Spatially Distributed Biophysical Balances: Application to Hippocampal Oriens-Lacunosum/Moleculare (O-LM) Cells

Vladislav Sekulić ,

* E-mail: vlad.sekulic@utoronto.ca

Affiliations Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
⨯
J. Josh Lawrence,

Affiliations NIH COBRE Center for Structural and Functional Neuroscience, University of Montana, Missoula, Montana, United States of America, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America
⨯
Frances K. Skinner

Affiliations Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada, Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
⨯

Using Multi-Compartment Ensemble Modeling As an Investigative Tool of Spatially Distributed Biophysical Balances: Application to Hippocampal Oriens-Lacunosum/Moleculare (O-LM) Cells

Vladislav Sekulić,
J. Josh Lawrence,
Frances K. Skinner

Published: October 31, 2014
https://doi.org/10.1371/journal.pone.0106567

About the Authors

Vladislav Sekulić

* E-mail: vlad.sekulic@utoronto.ca

Affiliations Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada

J. Josh Lawrence

Affiliations NIH COBRE Center for Structural and Functional Neuroscience, University of Montana, Missoula, Montana, United States of America, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, United States of America

Frances K. Skinner

Affiliations Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada, Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VS FKS JJL. Performed the experiments: VS JJL. Analyzed the data: VS JJL. Contributed reagents/materials/analysis tools: VS JJL FKS. Wrote the paper: VS JJL FKS.

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Neuronal dendrites
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Membrane potential
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Hippocampus
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Neurons
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Interneurons
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Ion channels
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Pyramidal cells
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Biophysics
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