About the Authors

Wenteh Chang

Affiliation Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Ke Wei

Affiliation Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Lawrence Ho

Affiliation Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

Gerald J. Berry

Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

Susan S. Jacobs

Affiliation Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Cheryl H. Chang

Affiliation Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Glenn D. Rosen

grosen@stanford.edu

Affiliation Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Competing Interests

This work was supported by a grant from the Takeda Corporation. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials except that requests for MLN0128 will need to be processed through and approved by the Takeda Corporation.

Author Contributions

Conceived and designed the experiments: WC GDR. Performed the experiments: WC KW GJB CHC. Analyzed the data: WC KW LH GJB GDR. Contributed reagents/materials/analysis tools: SSJ GJB. Wrote the paper: WC GDR. IRB Approval and Informed Consent: SSJ.