About the Authors

Jason A. Miranda

jason.miranda2@pfizer.com

Affiliation Neusentis Research Unit, Pfizer, Cambridge, United Kingdom

Phil Stanley

Affiliation Research Statistics, Clinical Research, Pfizer, Cambridge, United Kingdom

Katrina Gore

Affiliation Research Statistics, Clinical Research, Pfizer, Cambridge, United Kingdom

Jamie Turner

Affiliation Neusentis Research Unit, Pfizer, Cambridge, United Kingdom

Rebecca Dias

Affiliation Neusentis Research Unit, Pfizer, Cambridge, United Kingdom

Huw Rees

Affiliation Neusentis Research Unit, Pfizer, Cambridge, United Kingdom

Competing Interests

All work was funded by Pfizer LTD., the employer of all authors. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JAM HR PS KG. Performed the experiments: JAM JT HR. Analyzed the data: JAM PS. Contributed reagents/materials/analysis tools: JAM PS. Contributed to the writing of the manuscript: JAM PS KG HR RD.