About the Authors

Yinghui Zhou

Contributed equally to this work with: Yinghui Zhou, William M. Rideout III

yinghuizhou01@gmail.com

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

William M. Rideout III

Contributed equally to this work with: Yinghui Zhou, William M. Rideout III

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Angela Bressel

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Sireesha Yalavarthi

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Tong Zi

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Darren Potz

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Samuel Farlow

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Joelle Brodeur

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Anthony Monti

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Shailaja Reddipalli

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Qiurong Xiao

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Steve Bottega

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Bin Feng

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

M. Isabel Chiu

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Marcus Bosenberg

Affiliation Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Joerg Heyer

Affiliation Department of Research, AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Competing Interests

This work was entirely funded by AVEO Pharmaceuticals Inc. Marcus Bosenberg was a paid consultant to AVEO. All other authors are either current or previous employees of AVEO Pharmaceuticals. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YZ WMR MIC MB JH. Performed the experiments: YZ WMR AB SY TZ DP SF JB AM SR QX SB. Analyzed the data: YZ WMR AB SY TZ DP SF BF. Contributed reagents/materials/analysis tools: JB AM QX SB. Contributed to the writing of the manuscript: YZ WMR AB SY MIC MB JH.