Immunoprecipitation of Amyloid Fibrils by the Use of an Antibody that Recognizes a Generic Epitope Common to Amyloid Fibrils

Erin R. Greiner; Jeffery W. Kelly; Fernando L. Palhano

doi:10.1371/journal.pone.0105433

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Open Access

Peer-reviewed

Research Article

Immunoprecipitation of Amyloid Fibrils by the Use of an Antibody that Recognizes a Generic Epitope Common to Amyloid Fibrils

Erin R. Greiner,

Affiliation Departments of Chemistry and Molecular and Experimental Medicine and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Jeffery W. Kelly,

Affiliation Departments of Chemistry and Molecular and Experimental Medicine and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Fernando L. Palhano

* E-mail: palhano@bioqmed.ufrj.br

Affiliations Departments of Chemistry and Molecular and Experimental Medicine and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America, Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
⨯

Immunoprecipitation of Amyloid Fibrils by the Use of an Antibody that Recognizes a Generic Epitope Common to Amyloid Fibrils

Erin R. Greiner,
Jeffery W. Kelly,
Fernando L. Palhano

Published: August 21, 2014
https://doi.org/10.1371/journal.pone.0105433

About the Authors

Erin R. Greiner

Affiliation Departments of Chemistry and Molecular and Experimental Medicine and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

Jeffery W. Kelly

Fernando L. Palhano

* E-mail: palhano@bioqmed.ufrj.br

Affiliations Departments of Chemistry and Molecular and Experimental Medicine and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America, Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ERG JWK FLP. Performed the experiments: ERG FLP. Analyzed the data: ERG JWK FLP. Contributed reagents/materials/analysis tools: JWK FLP. Contributed to the writing of the manuscript: FLP.

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Amyloid proteins
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Immunoprecipitation
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Cerebrospinal fluid
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Alzheimer's disease
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Caenorhabditis elegans
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Acetones
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Acetone precipitation
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Cytoskeletal proteins
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