Upregulation of Intermediate-Conductance Ca2+-Activated K+ Channels (KCNN4) in Porcine Coronary Smooth Muscle Requires NADPH Oxidase 5 (NOX5)

Hope K. A. Gole; Darla L. Tharp; Douglas K. Bowles

doi:10.1371/journal.pone.0105337

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Peer-reviewed

Research Article

Upregulation of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels (KCNN4) in Porcine Coronary Smooth Muscle Requires NADPH Oxidase 5 (NOX5)

Hope K. A. Gole,

Affiliation Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri, United States of America
⨯
Darla L. Tharp,

Affiliation Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri, United States of America
⨯
Douglas K. Bowles

* E-mail: BowlesD@missouri.edu

Affiliations Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri, United States of America, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, Missouri, United States of America, Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri, United States of America
⨯

Upregulation of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels (KCNN4) in Porcine Coronary Smooth Muscle Requires NADPH Oxidase 5 (NOX5)

Hope K. A. Gole,
Darla L. Tharp,
Douglas K. Bowles

Published: August 21, 2014
https://doi.org/10.1371/journal.pone.0105337

About the Authors

Hope K. A. Gole

Affiliation Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri, United States of America

Darla L. Tharp

Affiliation Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri, United States of America

Douglas K. Bowles

* E-mail: BowlesD@missouri.edu

Affiliations Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri, United States of America, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, Missouri, United States of America, Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HKAG DLT DKB. Performed the experiments: HKAG DLT DKB. Analyzed the data: HKAG DLT DKB. Contributed reagents/materials/analysis tools: HKAG DLT DKB. Wrote the paper: HKAG DLT.

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Atherosclerosis
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Growth factors
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Smooth muscles
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Protein expression
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Transcription factors
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Transcriptional control
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Adenoviruses
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Luciferase
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