About the Authors

Marlies van Lent

Marlies.vanLent@radboudumc.nl

Affiliation Clinical Research Centre Nijmegen, Department of Pharmacology – Toxicology, Radboud University Medical Centre, Nijmegen, The Netherlands

John Overbeke

Affiliation Department of Primary and Community Care, Radboud University Medical Centre, Nijmegen, The Netherlands

Henk Jan Out

Affiliations Clinical Research Centre Nijmegen, Department of Pharmacology – Toxicology, Radboud University Medical Centre, Nijmegen, The Netherlands, Teva Pharmaceuticals, Amsterdam, The Netherlands

Competing Interests

The authors read the journal's policy and have the following conflicts: HJO is a paid employee from Teva Pharmaceuticals. JO is the immediate past-president of the World Association of Medical Editors (WAME). MvL reports no competing interests. This research was supported by an unrestricted educational grant from MSD, The Netherlands (Dutch subsidiary of Merck & Co., Inc). The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HJO JO MvL. Performed the experiments: HJO MvL. Analyzed the data: MvL. Wrote the paper: HJO JO MvL.