About the Authors

Jana Malikova

JM and NC are joint first authors on this work.

Affiliations Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic, Pediatric Endocrinology, Department of Pediatrics and Department of Clinical Research, University Children’s Hospital Bern, Bern, Switzerland

Núria Camats

JM and NC are joint first authors on this work.

Affiliation Pediatric Endocrinology, Department of Pediatrics and Department of Clinical Research, University Children’s Hospital Bern, Bern, Switzerland

Mónica Fernández-Cancio

Affiliation Pediatric Endocrinology, Vall d’Hebron Research Institute VHIR, CIBERER, Autonomous University, Barcelona, Spain

Karen Heath

Affiliation Institute of Medical and Molecular Genetics INGEMM, Hospital Universitario La Paz, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain

Isabel González

Affiliation Pediatric Endocrinology Service, Hospital Universitario La Paz, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain

María Caimarí

Affiliation Pediatric Endocrinology, Son Espases University Hospital, Palma de Mallorca, Spain

Miguel del Campo

Affiliation Genetic Service, Hospital Vall d’Hebron, Barcelona, Spain

Marian Albisu

Affiliation Pediatric Endocrinology, Vall d’Hebron Research Institute VHIR, CIBERER, Autonomous University, Barcelona, Spain

Stanislava Kolouskova

Affiliation Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic

Laura Audí

Affiliation Pediatric Endocrinology, Vall d’Hebron Research Institute VHIR, CIBERER, Autonomous University, Barcelona, Spain

Christa E. Flück

christa.flueck@dkf.unibe.ch

Affiliation Pediatric Endocrinology, Department of Pediatrics and Department of Clinical Research, University Children’s Hospital Bern, Bern, Switzerland

Competing Interests

The authors declare that Novo Nordisk A/S partly funded this study. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JM NC MFC LA CEF. Performed the experiments: JM NC MFC KH IG MC MdC MA SK LA CEF. Analyzed the data: JM NC MFC LA CEF. Contributed reagents/materials/analysis tools: KH IG MC MdC MA SK. Contributed to the writing of the manuscript: JM NC LA CEF. Clinical evaluations: KH IG MC MdC MA SK.