About the Authors

Petra Kraus

Affiliations Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore, Department of Biology, Clarkson University, Potsdam, New York, United States of America

Sivakamasundari V

Affiliation Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore

Hong Bing Yu

Affiliation Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore

Xing Xing

Affiliation Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore

Siew Lan Lim

Affiliation Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore

Thure Adler

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Juan Antonio Aguilar Pimentel

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Klinikum rechts der Isar der Technischen Universität München, Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Munich, Germany

Lore Becker

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Alexander Bohla

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Lillian Garrett

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Wolfgang Hans

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Sabine M. Hölter

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Eva Janas

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Kristin Moreth

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Cornelia Prehn

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Oliver Puk

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Birgit Rathkolb

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany

Jan Rozman

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Jerzy Adamski

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Raffi Bekeredjian

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Department of Medicine III, Division of Cardiology, University of Heidelberg, Heidelberg, Germany

Dirk H. Busch

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Munich, Germany

Jochen Graw

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Martin Klingenspor

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Technische Universität München, Freising-Weihenstephan, Germany

Thomas Klopstock

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany

Frauke Neff

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Markus Ollert

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Klinikum rechts der Isar der Technischen Universität München, Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Munich, Germany

Tobias Stoeger

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Ali Önder Yildrim

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Oliver Eickelberg

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Eckhard Wolf

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany

Wolfgang Wurst

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Chair of Developmental Biology, Technische Universität München, Freising-Weihenstephan, Germany, Max Planck Institute of Psychiatry, Munich, Germany, Deutsches Institut für Neurodegenerative Erkrankungen Site Munich, Munich, Germany, Munich Cluster for Systems Neurology, Munich, Germany

Helmut Fuchs

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Valérie Gailus-Durner

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Martin Hrabě de Angelis

Affiliations German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Chair of Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, Member of German Center for Diabetes Research, Neuherberg, Germany

Thomas Lufkin

Affiliations Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore, Department of Biology, Clarkson University, Potsdam, New York, United States of America

Lawrence W. Stanton

stantonl@gis.a-star.edu.sg

Affiliation Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore

Competing Interests

One or more of the authors are employed by a commercial company (German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)). The affiliation(s) to this company, along with any other relevant declarations relating to employment, consultancy, patents, products in development or marketed products etc. does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PK SV HBY XX SLL TA JAAP LB AB LG WH SMH EJ KM CP OP BR JR JA RB DHB JG MK TK FN MO TS AOY OE EW WW HF VGD MH TL LWS. Performed the experiments: PK SV HBY XX SLL TA JAAP LB AB LG WH SMH EJ KM CP OP BR JR JA RB DHB JG MK TK FN MO TS AOY OE EW WW HF VGD MH TL LWS. Analyzed the data: PK SV HBY XX SLL TA JAAP LB AB LG WH SMH EJ KM CP OP BR JR JA RB DHB JG MK TK FN MO TS AOY OE EW WW HF VGD MH TL LWS. Contributed reagents/materials/analysis tools: PK SV HBY XX SLL TA JAAP LB AB LG WH SMH EJ KM CP OP BR JR JA RB DHB JG MK TK FN MO TS AOY OE EW WW HF VGD MH TL LWS. Contributed to the writing of the manuscript: PK SV HBY XX SLL TA JAAP LB AB LG WH SMH EJ KM CP OP BR JR JA RB DHB JG MK TK FN MO TS AOY OE EW WW HF VGD MH TL LWS.