About the Authors

Yan Liu

Affiliations China State Institute of Pharmaceutical Industry, Zhangjiang Institute, Shanghai, China, Shanghai Institute of Pharmaceutical Industry, Shanghai, China

Liping Xie

Affiliations China State Institute of Pharmaceutical Industry, Zhangjiang Institute, Shanghai, China, Shanghai Institute of Pharmaceutical Industry, Shanghai, China

Guihua Gong

Affiliations China State Institute of Pharmaceutical Industry, Zhangjiang Institute, Shanghai, China, Shanghai Institute of Pharmaceutical Industry, Shanghai, China

Wei Zhang

Affiliations China State Institute of Pharmaceutical Industry, Zhangjiang Institute, Shanghai, China, Shanghai Institute of Pharmaceutical Industry, Shanghai, China

Baoquan Zhu

bebydou@hotmail.com (YH); baoquanzhu@sipi.com.cn (BZ)

Affiliation China State Institute of Pharmaceutical Industry, Zhangjiang Institute, Shanghai, China

Youjia Hu

bebydou@hotmail.com (YH); baoquanzhu@sipi.com.cn (BZ)

Affiliations China State Institute of Pharmaceutical Industry, Zhangjiang Institute, Shanghai, China, Shanghai Institute of Pharmaceutical Industry, Shanghai, China

Competing Interests

The authors have declared the following interest: All authors are employed by China State Institute of Pharmaceutical Industry, Zhangjiang Institute and/or Shanghai Institute of Pharmaceutical Industry. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: YH BZ. Performed the experiments: YL. Analyzed the data: LX. Contributed reagents/materials/analysis tools: GG. Contributed to the writing of the manuscript: WZ.