About the Authors

Catarina D. Campbell

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Kiana Mohajeri

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Maika Malig

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Fereydoun Hormozdiari

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Benjamin Nelson

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Gaixin Du

Affiliation Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America

Kristen M. Patterson

Affiliation Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America

Celeste Eng

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Dara G. Torgerson

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Donglei Hu

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Catherine Herman

Affiliation Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America

Jessica X. Chong

Affiliation Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America

Arthur Ko

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Brian J. O'Roak

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Niklas Krumm

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Laura Vives

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Choli Lee

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Lindsey A. Roth

Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

William Rodriguez-Cintron

Affiliation Veterans Caribbean Health Care System, San Juan, Puerto Rico, United States of America

Jose Rodriguez-Santana

Affiliation Centro de Neumología Pediátrica, San Juan, Puerto Rico, United States of America

Emerita Brigino-Buenaventura

Affiliation Department of Allergy & Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, California, United States of America

Adam Davis

Affiliation Children's Hospital and Research Center Oakland, Oakland, California, United States of America

Kelley Meade

Affiliation Children's Hospital and Research Center Oakland, Oakland, California, United States of America

Michael A. LeNoir

Affiliation Bay Area Pediatrics, Oakland, California, United States of America

Shannon Thyne

Affiliation San Francisco General Hospital, San Francisco, California, and the Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America

Daniel J. Jackson

Affiliation Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America

James E. Gern

Affiliation Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America

Robert F. Lemanske Jr

Affiliations Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Jay Shendure

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Mark Abney

Affiliation Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America

Esteban G. Burchard

Affiliations Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Carole Ober

Affiliation Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America

Evan E. Eichler

eee@gs.washington.edu

Affiliations Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America

Competing Interests

The authors of this manuscript have read the journal's policy and have the following competing interests: E.E.E. is on the scientific advisory board (SAB) of DNAnexus, Inc. and was an SAB member of Pacific Biosciences, Inc. (2009–2013) and SynapDx Corp. (2011–2013). This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CDC FH DGT MA EGB CO EEE. Performed the experiments: CDC K. Mohajeri MM FH BN GD KMP CE AK BJO LV CL. Analyzed the data: CDC K. Mohajeri MM FH GD DGT DH CH JXC BJO NK. Contributed reagents/materials/analysis tools: LAR WR-C JR-S EB-B AD K. Meade MAL ST DJJ JEG RFL JS. Contributed to the writing of the manuscript: CDC EEE.