About the Authors

J. Brian Jameson II

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America

Auric Kantz

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America

Lena Schultz

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

Chakrapani Kalyanaraman

Affiliation Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, California, United States of America

Matthew P. Jacobson

Affiliation Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, California, United States of America

David J. Maloney

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

Ajit Jadhav

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

Anton Simeonov

asimeono@mail.nih.gov (AS); tholman@chemistry.ucsc.edu (TRH)

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

Theodore R. Holman

asimeono@mail.nih.gov (AS); tholman@chemistry.ucsc.edu (TRH)

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America

Competing Interests

MPJ is a consultant to Schrodinger LLC, which develops and distributes software used in this study.

Author Contributions

Conceived and designed the experiments: JBJ DJM AJ AS TRH CK MPJ. Performed the experiments: JBJ AK LS AJ AS TRH CK MPJ. Analyzed the data: JBJ AK LS DJM AJ AS TRH CK MPJ. Contributed reagents/materials/analysis tools: JBJ AK LS DJM AJ AS TRH CK MPJ. Contributed to the writing of the manuscript: JBJ DJM AJ AS TRH CK MPJ.