About the Authors

Maria Sabater-Lleal

maria.sabater.lleal@ki.se

Affiliation Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Anders Mälarstig

Affiliation Pfizer Worldwide Research and Development, Cambridge, United Kingdom

Lasse Folkersen

Current address: PharmakoGenetics department, Novo Nordisk A/S, Bagsvaerd, Denmark

Affiliation Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

María Soler Artigas

Affiliations Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom, National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

Damiano Baldassarre

Affiliations Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Cattere Scientifico, Milan, Italy

Maryam Kavousi

Affiliation Department of Epidemiology, Erasmus Medical Center - University Medical Center Rotterdam, Rotterdam, the Netherlands

Peter Almgren

Affiliation Department of Clinical Sciences, Lunds University, Malmö, Sweden

Fabrizio Veglia

Affiliation Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Cattere Scientifico, Milan, Italy

Guy Brusselle

Affiliations Department of Epidemiology, Erasmus Medical Center - University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus Medical Center - University Medical Center Rotterdam, Rotterdam, the Netherlands, Inspectorate for Health Care, The Hague, the Netherlands

Albert Hofman

Affiliation Department of Epidemiology, Erasmus Medical Center - University Medical Center Rotterdam, Rotterdam, the Netherlands

Gunnar Engström

Affiliation Department of Clinical Sciences, Lunds University, Malmö, Sweden

Oscar H. Franco

Affiliation Department of Epidemiology, Erasmus Medical Center - University Medical Center Rotterdam, Rotterdam, the Netherlands

Olle Melander

Affiliations Department of Clinical Sciences, Lunds University, Malmö, Sweden, Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden

Gabrielle Paulsson-Berne

Affiliation Cardiovascular Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Hugh Watkins

Affiliation Department of Cardiovascular Medicine and the Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Per Eriksson

Affiliation Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Steve E. Humphries

Affiliation Center for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom

Elena Tremoli

Affiliations Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Cattere Scientifico, Milan, Italy

Ulf de Faire

Affiliation Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Martin D. Tobin

Affiliations Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom, National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom

Anders Hamsten

Affiliation Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Competing Interests

With regards to conflicts of interest, the authors have the following interests. Anders Mälarstig is employed by Pfizer Worldwide Research and Development and holds Pfizer stocks and options. Dr. Engström has disclosed being formerly employed by AstraZeneca R&D. Dr. Folkersen is currently employed at Novo Nordisk A/S, Denmark although all his contributions in this manuscript were done when employed at Karolinska Institutet. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MS-L AM MSA MDT A. Hamsten. Analyzed the data: MS-L LF MSA DB MK PA FV. Contributed reagents/materials/analysis tools: GB AH GE OHF OM GPB HW PE SEH ET UdF. Contributed to the writing of the manuscript: MS-L AM MSA DB GE SEH MDT A. Hamsten. Performed statistical analyses: A. Hofman.