About the Authors

Maureen J. Donlin

Affiliations Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Elena Lomonosova

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Alexi Kiss

Current address: Division of Dermatology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States of America

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Xiaohong Cheng

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Feng Cao

Current address: John Cochran Division, Department of Veteran’s Affairs Medical Center, St. Louis, Missouri, United States of America

Affiliations Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Teresa M. Curto

Affiliation New England Research Institutes, Inc., Watertown, Massachusetts, United States of America

Adrian Di Bisceglie

Affiliations Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

John E. Tavis

tavisje@slu.edu

Affiliations Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Saint Louis Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Competing Interests

Both MD and JT are Academic Editors for PLOS ONE. The authors both confirm that this does not alter their adherence to PLOS ONE Editorial policies and criteria. Additionally, no funding was directly received from Hoffmann-La Roche in support of this project. The HALT-C clinical trial from which some of the samples were derived received funding from Hoffman La Roche. However, HALT-C was funded and conducted independently of the authors’ viral genetics study, so no commercial funding was directly spent in support of this viral genetics project. Effort expended by the HALT-C personnel in support of this project was paid for by National Institutes of Health grant DK045715 to JT through a subcontract with the HALT-C Data Coordinating Center at the New England Research Institute. Despite this separation in funding sources, the authors included the funding sources for the HALT-C trial in our disclosures to provide full transparency. Therefore, the disclosure in the initial submission was complete and accurate, and an amendment of the conflict of interest statement does not appear to be needed. The authors attest that the funding of the parental HALT-C study by a commercial sources does not alter their adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MJD ADB JET. Performed the experiments: EL AK XC FC. Analyzed the data: MJD TMC JET. Contributed to the writing of the manuscript: MJD JET.