Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Bistra B. Nankova; Raj Agarwal; Derrick F. MacFabe; Edmund F. La Gamma

doi:10.1371/journal.pone.0103740

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Peer-reviewed

Research Article

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Bistra B. Nankova ,

* E-mail: bistra_nankova@nymc.edu

Affiliation New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America
⨯
Raj Agarwal,

Affiliation New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America
⨯
Derrick F. MacFabe,

Affiliation The Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry, Division of Developmental Disabilities, The University of Western Ontario, London, Ontario, Canada
⨯
Edmund F. La Gamma

Affiliation New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America
⨯

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Bistra B. Nankova,
Raj Agarwal,
Derrick F. MacFabe,
Edmund F. La Gamma

Published: August 29, 2014
https://doi.org/10.1371/journal.pone.0103740

About the Authors

Bistra B. Nankova

* E-mail: bistra_nankova@nymc.edu

Affiliation New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America

Raj Agarwal

Affiliation New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America

Derrick F. MacFabe

Affiliation The Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry, Division of Developmental Disabilities, The University of Western Ontario, London, Ontario, Canada

Edmund F. La Gamma

Affiliation New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BN ELG DM. Performed the experiments: BN RA. Analyzed the data: BN ELG RA. Contributed reagents/materials/analysis tools: BN ELG DM. Contributed to the writing of the manuscript: BN DM ELG.

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Gene expression
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Gene regulation
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Transcription factors
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Autism spectrum disorder
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Mitochondria
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Fatty acids
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Transcriptional control
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DNA-binding proteins
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