About the Authors

Alejandro Arenas-Pinto

A.Arenas-Pinto@ucl.ac.uk

Affiliations MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, United Kingdom, Centre for Sexual Health and HIV Research, University College London, London, United Kingdom

Alan Winston

Affiliations Section of Infectious Diseases, Division of Medicine, Imperial College, St Mary’s Hospital Campus, London, United Kingdom, Department of HIV and GU Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom

Wolfgang Stöhr

Affiliation MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, United Kingdom

John Day

Affiliation Infectious Diseases, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, United Kingdom

Rebecca Wiggins

Affiliation Centre for Immunology and Infection, Department of Biology, University of York, York, United Kingdom

Say Pheng Quah

Affiliation Department of GU Medicine, Royal Victoria Hospital, Belfast, United Kingdom

Jonathan Ainsworth

Affiliation Infectious Diseases, North Middlesex University Hospital, London, United Kingdom

Sue Fleck

Affiliation MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, United Kingdom

David Dunn

Affiliation MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, United Kingdom

Alex Accoroni

Affiliation Psychology and Psychotherapy Department, The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom

Nicholas I. Paton

Affiliations MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, United Kingdom, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

for the PIVOT Trial Team

Membership of the PIVOT Trial Team is provided in the acknowledgements

Competing Interests

The authors have read the journal’s policy and have the following conflicts: Dr Alejandro Arenas-Pinto has received honoraria or research grants, or been investigator, in clinical trials sponsored by Abbott, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, Pfizer, ViiV Healthcare and Janssen Cilag. Dr Alan Winston holds grants from the British Medical Research Council and the European Union (Framework 7). Has received honoraria or research grants, or been a consultant or investigator, in clinical trials sponsored by Abbott, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Janssen Cilag, Roche, Pfizer and ViiV Healthcare. Prof N Paton has received honoraria from Roche / Genentec for work on a DSMB; from AbbVie and Merck and Jansssen for speaking at meetings / attending advisory boards; and has received grant funding or donations of drugs for research studies from GSK, Gilead, Merck, Abbvie, Janssen and Pfizer. This does not alter their adherence to PLOS ONE policies on sharing data and materials. The rest of the authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AAP AW DD AA NP. Performed the experiments: AAP AW JD RW SPQ JA SF. Analyzed the data: WS DD. Contributed reagents/materials/analysis tools: SF. Wrote the paper: AAP AW WS DD AA NP.