Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

Wensheng Yan; Yong-Sam Jung; Yanhong Zhang; Xinbin Chen

doi:10.1371/journal.pone.0103497

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Open Access

Peer-reviewed

Research Article

Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

Wensheng Yan,

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America
⨯
Yong-Sam Jung,

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America
⨯
Yanhong Zhang,

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America
⨯
Xinbin Chen

* E-mail: xbchen@ucdavis.edu

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America
⨯

Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

Wensheng Yan,
Yong-Sam Jung,
Yanhong Zhang,
Xinbin Chen

Published: August 12, 2014
https://doi.org/10.1371/journal.pone.0103497

About the Authors

Wensheng Yan

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America

Yong-Sam Jung

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America

Yanhong Zhang

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America

Xinbin Chen

* E-mail: xbchen@ucdavis.edu

Affiliation Comparative Oncology Laboratory, School of Medicine and Veterinary Medicine, University of California at Davis, Davis, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WY YJ YZ XC. Performed the experiments: WY YJ YZ. Analyzed the data: WY YJ YZ XC. Contributed reagents/materials/analysis tools: WY YJ YZ XC. Contributed to the writing of the manuscript: WY XC.

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Ligases
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Arsenic
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Malignant tumors
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Immunoprecipitation
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Cancer treatment
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Small interfering RNA
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Cancers and neoplasms
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Proteasomes
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