NAC Attenuates LPS-Induced Toxicity in Aspirin-Sensitized Mouse Macrophages via Suppression of Oxidative Stress and Mitochondrial Dysfunction

Haider Raza; Annie John; Jasmin Shafarin

doi:10.1371/journal.pone.0103379

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Open Access

Peer-reviewed

Research Article

NAC Attenuates LPS-Induced Toxicity in Aspirin-Sensitized Mouse Macrophages via Suppression of Oxidative Stress and Mitochondrial Dysfunction

Haider Raza ,

* E-mail: h.raza@uaeu.ac.ae

Affiliation Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
⨯
Annie John,

Affiliation Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
⨯
Jasmin Shafarin

Affiliation Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
⨯

NAC Attenuates LPS-Induced Toxicity in Aspirin-Sensitized Mouse Macrophages via Suppression of Oxidative Stress and Mitochondrial Dysfunction

Haider Raza,
Annie John,
Jasmin Shafarin

Published: July 30, 2014
https://doi.org/10.1371/journal.pone.0103379

About the Authors

Haider Raza

* E-mail: h.raza@uaeu.ac.ae

Affiliation Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

Annie John

Affiliation Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

Jasmin Shafarin

Affiliation Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HR. Performed the experiments: HR AJ JS. Analyzed the data: HR AJ JS. Contributed reagents/materials/analysis tools: HR AJ JS. Contributed to the writing of the manuscript: HR AJ.

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Macrophages
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Mitochondria
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Apoptosis
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Cytokine therapy
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Oxidative stress
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Cytokines
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Toxicity
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Membrane potential
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