Gene Silencing Mediated by Endogenous MicroRNAs under Heat Stress Conditions in Mammalian Cells

Masashi Fukuoka; Mariko Yoshida; Akiko Eda; Masaki Takahashi; Hirohiko Hohjoh

doi:10.1371/journal.pone.0103130

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Open Access

Peer-reviewed

Research Article

Gene Silencing Mediated by Endogenous MicroRNAs under Heat Stress Conditions in Mammalian Cells

Masashi Fukuoka ,

Contributed equally to this work with: Masashi Fukuoka, Mariko Yoshida

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
⨯
Mariko Yoshida ,

Contributed equally to this work with: Masashi Fukuoka, Mariko Yoshida

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
⨯
Akiko Eda,

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
⨯
Masaki Takahashi,

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
⨯
Hirohiko Hohjoh

* E-mail: hohjohh@ncnp.go.jp

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
⨯

Gene Silencing Mediated by Endogenous MicroRNAs under Heat Stress Conditions in Mammalian Cells

Masashi Fukuoka,
Mariko Yoshida,
Akiko Eda,
Masaki Takahashi,
Hirohiko Hohjoh

Published: July 28, 2014
https://doi.org/10.1371/journal.pone.0103130

About the Authors

Masashi Fukuoka

Contributed equally to this work with: Masashi Fukuoka, Mariko Yoshida

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

Mariko Yoshida

Contributed equally to this work with: Masashi Fukuoka, Mariko Yoshida

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

Akiko Eda

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

Masaki Takahashi

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

Hirohiko Hohjoh

* E-mail: hohjohh@ncnp.go.jp

Affiliation Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HH MF. Performed the experiments: MF MY AE MT HH. Analyzed the data: MF MY AE MT HH. Contributed reagents/materials/analysis tools: HH. Wrote the paper: MF HH.

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MicroRNAs
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Gene silencing
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HeLa cells
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Hyperthermia
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Heat shock response
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Small interfering RNA
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Transfection
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Luciferase
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