About the Authors

Sofie M. Adriaanse

s.adriaanse@vumc.nl

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Maja A. A. Binnewijzend

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Rik Ossenkoppele

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Betty M. Tijms

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Wiesje M. van der Flier

Affiliations Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Department of Epidemiology and biostatistics, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Teddy Koene

Affiliation Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands

Lieke L. Smits

Affiliations Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Alle Meije Wink

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Philip Scheltens

Affiliations Department of Neurology/Alzheimercenter Amsterdam, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Bart N. M. van Berckel

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Frederik Barkhof

Affiliations Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands

Competing Interests

S.M. Adriaanse, M.A.A. Binnewijzend, R. Ossenkoppele, B.M. Tijms, W.M. van der Flier, T. Koene and L.L. Smits report no disclosures. A. Wink was funded by VUmc radiology, the neuroscience Campus Amsterdam and the Dutch MS Research Foundation (grant no. 08–650). Dr. Wink receives no personal compensation for this. Dr. Scheltens receives grant support (for the institution; the VUmc Alzheimer center, see also below) from GE Healthcare, Danone Researcrh and MERCK. In the past 2 years he has received speaker’s fees (paid to the institution) from Lilly, GE Healthcare, Lundbeck, Danone and Jansen AI-Pfizer. B.N.M. van Berckel receives research support from the Alzheimer Assistance Foundation, the Center for Translational Molecular Imaging, the Alzheimer Association, De Hersenstichting Nederland and the Internationale Stichting Alzheimer Onderzoek. Dr. van Berckel receives no personal compensation from these organizations. F. Barkhof serves on the editorial boards of Brain, European Radiology, Radiology, Multiple Sclerosis and Neuroradiology and serves as a consultant for Bayer-Shering Pharma, Sanofi-Aventis, Biogen-Idec, EVA, Synthon BV, Merck-Serono, Jansen Alzheimer Immunotherapy, Novartis and Roche. Dr. Barkhof receives research support from the Dutch MS Society (EU-FP7). Dr. Barkhof has received consulting fees or honoraria for the consultancy mentioned above. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BT WMF AW PS BB FB. Performed the experiments: SA MB RO TK LS. Analyzed the data: SA MB RO LS. Wrote the paper: SA RO BT AW BB FB.