About the Authors

Yukari Sadamura-Takenaka

Affiliations Department of Pulmonary Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Takashi Ito

Affiliation Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Satoshi Noma

Affiliations Department of Pulmonary Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Yoko Oyama

Affiliation Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Shingo Yamada

Affiliation Shino-Test Corporation, Sagamihara, Japan

Ko-ichi Kawahara

Affiliation Department of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan

Hiromasa Inoue

Affiliation Department of Pulmonary Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Ikuro Maruyama

maruyama@m2.kufm.kagoshima-u.ac.jp

Affiliation Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Competing Interests

Takashi Ito and Ikuro Maruyama hold endowed faculty positions in thrombosis research and have received funds from Medipolis Medical Research Institute, Shin Nippon Biomedical Laboratories, Asahi Kasei Pharma, and Asahi Kasei Medical. Hiromasa Inoue has received grants from Astellas, GlaxoSmithKline, Ono Pharma, and Novartis. Shingo Yamada is employed by Shino-Test Corporation. Anti-HMGB1 neutralizing IgY is a product of Shino-Test Corporation. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TI KK IM. Performed the experiments: YST. Analyzed the data: SN YO SY HI. Contributed reagents/materials/analysis tools: SY. Wrote the paper: TI KK IM.