About the Authors

Rui Wang

Contributed equally to this work with: Rui Wang, Yanwen Wang

These authors are joint first authors on this work.

Affiliation Institute for Cardiovascular Diseases, Union Hospital, Huazhong University of Science and Technology, Wuhan, P. R. China

Yanwen Wang

Contributed equally to this work with: Rui Wang, Yanwen Wang

Affiliations Institute of Cardiovascular Sciences, Faculty of Medicine and Human Science, University of Manchester, Manchester, United Kingdom, Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Wee K. Lin

Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Yanmin Zhang

Affiliation Institute of Cardiovascular Sciences, Faculty of Medicine and Human Science, University of Manchester, Manchester, United Kingdom

Wei Liu

Affiliation Institute of Cardiovascular Sciences, Faculty of Medicine and Human Science, University of Manchester, Manchester, United Kingdom

Kai Huang

Affiliation Institute for Cardiovascular Diseases, Union Hospital, Huazhong University of Science and Technology, Wuhan, P. R. China

Derek A. Terrar

Affiliation Department of Pharmacology, University of Oxford, Oxford, United Kingdom

R. John Solaro

RJS, XW, YK, and ML are joint senior authors on this work.

Affiliation Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

Xin Wang

RJS, XW, YK, and ML are joint senior authors on this work.

Affiliation Faculty of Life Science, University of Manchester, Manchester, United Kingdom

Yunbo Ke

yke@uic.edu (YK); ming.lei@pharm.ox.ac.uk (ML)

RJS, XW, YK, and ML are joint senior authors on this work.

Affiliation Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

Ming Lei

yke@uic.edu (YK); ming.lei@pharm.ox.ac.uk (ML)

RJS, XW, YK, and ML are joint senior authors on this work.

Affiliations Institute for Cardiovascular Diseases, Union Hospital, Huazhong University of Science and Technology, Wuhan, P. R. China, Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML YK XW RJS. Performed the experiments: RW YW WKL YZ WL. Analyzed the data: RW YW WKL YZ WL. Contributed reagents/materials/analysis tools: DAT KH. Wrote the paper: ML YK. Provide experimental expertise advice: DAT.