About the Authors

Walt F. Lima

wlima@isisph.com

Affiliation Isis Pharmaceuticals Inc., Carlsbad, California, United States of America

Timothy A. Vickers

Affiliation Isis Pharmaceuticals Inc., Carlsbad, California, United States of America

Josh Nichols

Affiliation Isis Pharmaceuticals Inc., Carlsbad, California, United States of America

Cheryl Li

Affiliation Isis Pharmaceuticals Inc., Carlsbad, California, United States of America

Stanley T. Crooke

Affiliation Isis Pharmaceuticals Inc., Carlsbad, California, United States of America

Competing Interests

The authors have the following interests: Authors Walt F. Lima, Timothy A. Vickers, Josh Nichols, Cheryl Li and Stanley T. Crooke are employed by a commercial company, Isis Pharmaceuticals Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WL TV SC. Performed the experiments: TV JN CL. Analyzed the data: WL TV SC. Wrote the paper: WL TV SC.