About the Authors

Nobu Oshima

Affiliations Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Department of Fundamental Cell Technology, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Yasuhiro Yamada

Affiliation Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

Satoshi Nagayama

Affiliations Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Department of Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

Kenji Kawada

Affiliation Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Suguru Hasegawa

Affiliation Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Hiroshi Okabe

Affiliation Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Yoshiharu Sakai

Affiliation Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Takashi Aoi

takaaoi@med.kobe-u.ac.jp

Affiliations Department of Fundamental Cell Technology, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Department of iPS cell Applications, Graduate School of Medicine, Kobe University, Kobe, Japan

Competing Interests

NO and TA are members without salary of Shinryoku-Kai General Incorporated Association which is a not for profit alumni association of Kobe University school of medicine. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NO TA. Performed the experiments: NO. Analyzed the data: NO. Wrote the paper: NO TA. Histopathological analysis of the xenografts: YY. Interpretation and providing critical revision of the manuscripts for intellectual content: YY SN KK SH HO YS. Final approval of the version to be published: NO TA. Supervision of the project: TA.