Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

Katherine R. Sadleir; William A. Eimer; Randal J. Kaufman; Pavel Osten; Robert Vassar

doi:10.1371/journal.pone.0101643

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Peer-reviewed

Research Article

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

Katherine R. Sadleir,

Affiliation Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
William A. Eimer,

Affiliation Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Randal J. Kaufman,

Affiliation Sanford|Burnham Medical Research Institute, La Jolla, California, United States of America
⨯
Pavel Osten,

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
⨯
Robert Vassar

* E-mail: r-vassar@northwestern.edu

Affiliation Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

Katherine R. Sadleir,
William A. Eimer,
Randal J. Kaufman,
Pavel Osten,
Robert Vassar

Published: July 3, 2014
https://doi.org/10.1371/journal.pone.0101643

About the Authors

Katherine R. Sadleir

Affiliation Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America

William A. Eimer

Affiliation Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Randal J. Kaufman

Affiliation Sanford|Burnham Medical Research Institute, La Jolla, California, United States of America

Pavel Osten

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

Robert Vassar

* E-mail: r-vassar@northwestern.edu

Affiliation Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KRS RV. Performed the experiments: KRS WAE. Analyzed the data: KRS RV. Contributed reagents/materials/analysis tools: RJK PO. Contributed to the writing of the manuscript: KRS RV.

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Phosphorylation
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Neurons
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Mouse models
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Genetically modified animals
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Hippocampus
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Oligomers
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Messenger RNA
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Protein translation
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