About the Authors

Elin Törnqvist

Affiliations Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Former AstraZeneca R&D, Södertälje, Sweden

Anita Annas

Affiliation Former AstraZeneca R&D, Södertälje, Sweden

Britta Granath

Affiliations Former AstraZeneca R&D, Södertälje, Sweden, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Elisabeth Jalkesten

Affiliations Former AstraZeneca R&D, Södertälje, Sweden, Karolinska University Hospital, Stockholm, Sweden

Ian Cotgreave

Affiliations Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Former AstraZeneca R&D, Södertälje, Sweden, Swedish Toxicology Sciences Research Center, Södertälje, Sweden

Mattias Öberg

mattias.oberg@ki.se

Affiliations Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Swedish Toxicology Sciences Research Center, Södertälje, Sweden

Competing Interests

Elin Törnqvist, Anita Annas, Britta Granath, Elisabeth Jalkesten and Ian Cotgreave were previously employed by AstraZeneca R & D. The data used in this study comes from a former AstraZeneca Unit. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: ET AA BG EJ IC MÖ. Performed the experiments: ET AA BG EJ IC. Analyzed the data: ET MÖ. Contributed reagents/materials/analysis tools: ET AA BG EJ IC. Contributed to the writing of the manuscript: ET AA BG EJ IC MÖ.