About the Authors

Haiyu Xu

Contributed equally to this work with: Haiyu Xu, Yanqiong Zhang, Yun Lei

Affiliations Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China, National resource center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Yanqiong Zhang

Contributed equally to this work with: Haiyu Xu, Yanqiong Zhang, Yun Lei

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Yun Lei

Contributed equally to this work with: Haiyu Xu, Yanqiong Zhang, Yun Lei

Affiliations Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China, Beijing University of Chinese Medicine, Beijing, P.R. China

Xiumei Gao

Affiliations Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China

Huaqiang Zhai

Affiliation Beijing University of Chinese Medicine, Beijing, P.R. China

Na Lin

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Shihuan Tang

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Rixin Liang

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Yan Ma

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Defeng Li

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Yi Zhang

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Guangrong Zhu

Affiliation Yunnan Datang Hanfang Pharmacy co.ltd, Yunnan, P.R. China

Hongjun Yang

hongjun0420@vip.sina.com (HY); huangluqi@263.net (LH)

Affiliation Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Luqi Huang

hongjun0420@vip.sina.com (HY); huangluqi@263.net (LH)

Affiliation National resource center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China

Competing Interests

Guangrong Zhu is an employee of Datang Hanfang Pharmacy co.ltd, and received funding in the form of salary. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XG GZ HY LH. Performed the experiments: HX Yanqiong Z. YL HZ RL DL Yi Z. Analyzed the data: NL ST. Contributed to the writing of the manuscript: YM.