A Characteristic Back Support Structure in the Bisphenol A-Binding Pocket in the Human Nuclear Receptor ERRγ

Xiaohui Liu; Ayami Matsushima; Miki Shimohigashi; Yasuyuki Shimohigashi

doi:10.1371/journal.pone.0101252

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Open Access

Peer-reviewed

Research Article

A Characteristic Back Support Structure in the Bisphenol A-Binding Pocket in the Human Nuclear Receptor ERRγ

Xiaohui Liu,

Affiliation Laboratory of Structure-Function Biochemistry, Department of Chemistry, Faculty of Sciences, and Risk Science Research Center, Kyushu University, Fukuoka, Japan
⨯
Ayami Matsushima,

Affiliation Laboratory of Structure-Function Biochemistry, Department of Chemistry, Faculty of Sciences, and Risk Science Research Center, Kyushu University, Fukuoka, Japan
⨯
Miki Shimohigashi,

Affiliation Division of Biology, Faculty of Science, Fukuoka University, Fukuoka, Japan
⨯
Yasuyuki Shimohigashi

* E-mail: shimo@ kyudai.jp

Affiliation Laboratory of Structure-Function Biochemistry, Department of Chemistry, Faculty of Sciences, and Risk Science Research Center, Kyushu University, Fukuoka, Japan
⨯

A Characteristic Back Support Structure in the Bisphenol A-Binding Pocket in the Human Nuclear Receptor ERRγ

Xiaohui Liu,
Ayami Matsushima,
Miki Shimohigashi,
Yasuyuki Shimohigashi

Published: June 30, 2014
https://doi.org/10.1371/journal.pone.0101252

About the Authors

Xiaohui Liu

Affiliation Laboratory of Structure-Function Biochemistry, Department of Chemistry, Faculty of Sciences, and Risk Science Research Center, Kyushu University, Fukuoka, Japan

Ayami Matsushima

Affiliation Laboratory of Structure-Function Biochemistry, Department of Chemistry, Faculty of Sciences, and Risk Science Research Center, Kyushu University, Fukuoka, Japan

Miki Shimohigashi

Affiliation Division of Biology, Faculty of Science, Fukuoka University, Fukuoka, Japan

Yasuyuki Shimohigashi

* E-mail: shimo@ kyudai.jp

Affiliation Laboratory of Structure-Function Biochemistry, Department of Chemistry, Faculty of Sciences, and Risk Science Research Center, Kyushu University, Fukuoka, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XL AM YS. Performed the experiments: XL. Analyzed the data: XL YS. Contributed reagents/materials/analysis tools: XL AM MS YS. Contributed to the writing of the manuscript: XL YS.

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Receptor binding assays
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Binding analysis
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Benzene
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Hydrogen bonding
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Amino acid analysis
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Protein expression
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Crystal structure
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Receptor physiology
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