About the Authors

Carol Lozano-Santos

Affiliation Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Jimena Martinez-Velasquez

Affiliation Group of Immunogenetics, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Belen Fernandez-Cuevas

Affiliation Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Natividad Polo

Affiliation Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Belen Navarro

Affiliation Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Isabel Millan

Affiliation Department of Statistics, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Jose Miguel Garcia

Affiliation Group of Oncology, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Rosa Collado

Affiliation Department of Hematology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain

Pedro Sanchez-Godoy

Affiliation Department of Hematology, Hospital Severo Ochoa de Madrid, Madrid, Spain

Felix Carbonell

Affiliation Department of Hematology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain

Jose Antonio Garcia-Vela

Affiliation Department of Hematology, Hospital Universitario Ramón y Cajal de Madrid, Madrid, Spain

Jose Antonio Garcia-Marco

Contributed equally to this work with: Jose Antonio Garcia-Marco, Natalia Gomez-Lozano

Affiliation Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Natalia Gomez-Lozano

Contributed equally to this work with: Jose Antonio Garcia-Marco, Natalia Gomez-Lozano

ngomez@idiphim.org

Affiliation Group of Immunogenetics, Hospital Universitario Puerta de Hierro Majadahonda & Instituto de Investigación Puerta de Hierro Majadahonda (IDIPHIM), Madrid, Spain

Competing Interests

CLS received funding from Roche Farma for this work and has no other relationships, conditions or circumstances that present potential competing interests related with this work. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials. The rest of the authors declare no competing interests related with this work.

Author Contributions

Conceived and designed the experiments: NGL. Performed the experiments: CLS JMV. Analyzed the data: JAGM NGL. Wrote the paper: NGL. Obtained the cytogenetic and molecular data: BFC NP RC JAGM. Provided clinical cases to the study: PSG FC JAGV BN JAGM. Performed the immunophenotyping analyses: JAGV. Reviewed the statistical analysis: IM JMG. Analysed the data: NGL JAGM CLS.