About the Authors

Yongsheng Bai

Contributed equally to this work with: Yongsheng Bai, Justin Hassler

Affiliations Department of Computational Medicine and Bioinformatics, and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Morgridge Institute for Research, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Justin Hassler

Contributed equally to this work with: Yongsheng Bai, Justin Hassler

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

Ahdad Ziyar

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

Philip Li

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

Zachary Wright

Affiliation Department of Computational Medicine and Bioinformatics, and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

Rajasree Menon

Affiliation Department of Computational Medicine and Bioinformatics, and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

Gilbert S. Omenn

Affiliations Department of Computational Medicine and Bioinformatics, and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Departments of Internal Medicine and Human Genetics, and School of Public Health, University of Michigan, United States of America, Institute for Systems Biology, Seattle, Washington, United States of America

James D. Cavalcoli

Affiliation Department of Computational Medicine and Bioinformatics, and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

Randal J. Kaufman

rkaufman@sanfordburnham.org (RJK); sartorma@umich.edu (MAS)

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

Maureen A. Sartor

rkaufman@sanfordburnham.org (RJK); sartorma@umich.edu (MAS)

Affiliations Department of Computational Medicine and Bioinformatics, and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAS JDC YB JH RJK. Performed the experiments: JH AZ PL RJK. Analyzed the data: YB RM GSO ZW. Wrote the paper: YB JH RM ZW GSO JDC RJK MAS.