About the Authors

Stephanie J. B. Vos

s.vos@maastrichtuniversity.nl

Affiliation Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands

Pieter Jelle Visser

Affiliations Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands, Alzheimer center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

Frans Verhey

Affiliation Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands

Pauline Aalten

Affiliation Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands

Dirk Knol

Affiliation Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands

Inez Ramakers

Affiliation Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands

Philip Scheltens

Affiliation Alzheimer center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

Marcel G. M. Olde. Rikkert

Affiliations Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen and Radboud Alzheimer Centre, Nijmegen, The Netherlands

Marcel M. Verbeek

Affiliations Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen and Radboud Alzheimer Centre, Nijmegen, The Netherlands, Department of Neurology and Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Charlotte E. Teunissen

Affiliation Department of Clinical Chemistry, Neurological Laboratory, VU University Medical Center, Amsterdam, The Netherlands

Competing Interests

Dr. Visser has served as an advisory board member of Bristol-Myers Squibb. He receives/received research grants from Zon-Mw as part of the BIOMARKAPD project in the frame of the European Joint Programming Initiative on Neurodegenerative Disorders (JPND), Innovative Medicines Initiative (IMI) as part of the EMIF-AD project, Bristol-Myers Squibb, European Commission 6th and 7th Framework programme, Life Sciences, Genomics and Biotechnology for Health. Dr. Verhey serves on the advisory board of Nutricia Medical Food bv. Dr. Scheltens serves/has served on the advisory boards of Genentech, Novartis, Roche, Danone, Nutricia, Baxter, and Lundbeck. He has been a speaker at symposia organized by Lundbeck, Merz, Danone, Novartis, Roche, and Genentech. For all his activities he receives no personal compensation. He is a member of the scientific advisory board of the EU Joint Programming Initiative and the French National Plan Alzheimer. The Alzheimer Center receives unrestricted funding from various sources through the VUmc Fonds. Dr. Teunissen serves at the advisory boards of Roche and Innogenetics. The authors confirm that this does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SV FV. Performed the experiments: MV CT. Analyzed the data: SV DK. Contributed to the writing of the manuscript: SV PJV CT. Reviewed the manuscript for intellectual content and approved the final draft: SV PJV FV PA DK IR PS MO MV CT. Involved in data collection: SV FV PA IR PS MO.