About the Authors

Jasmin F. Sydow

Current address: Novo Nordisk A/S, Biopharmaceutical Research Unit, Department of Protein Characterisation, Måløv, Denmark

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Florian Lipsmeier

Affiliation Therapeutics Modalities Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Vincent Larraillet

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Maximiliane Hilger

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Bjoern Mautz

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Michael Mølhøj

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Jan Kuentzer

Affiliation Disease & Translational Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Stefan Klostermann

Affiliation Therapeutics Modalities Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Juergen Schoch

Affiliation Therapeutics Modalities Informatics, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Hans R. Voelger

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Joerg T. Regula

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Patrick Cramer

Affiliation Gene Center Munich and Department of Biochemistry, Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität (LMU), Munich, Germany

Apollon Papadimitriou

Affiliation Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Hubert Kettenberger

hubert.kettenberger@roche.com

Affiliation Large Molecule Research, Roche Pharmaceutical Research and Early Development, Penzberg, Germany

Competing Interests

The authors have read the journal's policy and have the following conflicts: J.F.S. is a former employee of Roche. All other authors, except P.C., are current employees of Roche. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JFS HK PC AP JTR. Performed the experiments: JFS BM VL. Analyzed the data: JFS HK FL VL BM MH MM. Contributed reagents/materials/analysis tools: JK SK JS HRV. Wrote the paper: JFS HK.