Isoaspartyl Formation in Creatine Kinase B Is Associated with Loss of Enzymatic Activity; Implications for the Linkage of Isoaspartate Accumulation and Neurological Dysfunction in the PIMT Knockout Mouse

Aleksandra Dimitrijevic; Zhenxia Qin; Dana W. Aswad

doi:10.1371/journal.pone.0100622

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Peer-reviewed

Research Article

Isoaspartyl Formation in Creatine Kinase B Is Associated with Loss of Enzymatic Activity; Implications for the Linkage of Isoaspartate Accumulation and Neurological Dysfunction in the PIMT Knockout Mouse

Aleksandra Dimitrijevic,

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America
⨯
Zhenxia Qin,

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America
⨯
Dana W. Aswad

* E-mail: dwaswad@uci.edu

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America
⨯

Isoaspartyl Formation in Creatine Kinase B Is Associated with Loss of Enzymatic Activity; Implications for the Linkage of Isoaspartate Accumulation and Neurological Dysfunction in the PIMT Knockout Mouse

Aleksandra Dimitrijevic,
Zhenxia Qin,
Dana W. Aswad

Published: June 23, 2014
https://doi.org/10.1371/journal.pone.0100622

About the Authors

Aleksandra Dimitrijevic

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America

Zhenxia Qin

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America

Dana W. Aswad

* E-mail: dwaswad@uci.edu

Affiliation Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AD DWA. Performed the experiments: AD ZQ. Analyzed the data: AD ZQ DWA. Contributed reagents/materials/analysis tools: DWA. Contributed to the writing of the manuscript: AD ZQ DWA.

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Creatine
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Mouse models
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DNA repair
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Methylation
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Oxidation
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Brain damage
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Central nervous system
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Epileptic seizures
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