About the Authors
- James L. Sherwood
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* E-mail: James.Sherwood@AstraZeneca.com
Affiliation Personalised Healthcare & Biomarkers, AstraZeneca, Macclesfield, United Kingdom
- Susanne Müller
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Affiliation Sequenom GmbH, Hamburg, Germany
- Maria C. M. Orr
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Affiliation Personalised Healthcare & Biomarkers, AstraZeneca, Macclesfield, United Kingdom
- Marianne J. Ratcliffe
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Affiliation Personalised Healthcare & Biomarkers, AstraZeneca, Macclesfield, United Kingdom
- Jill Walker
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Affiliation Personalised Healthcare & Biomarkers, AstraZeneca, Macclesfield, United Kingdom
Competing Interests
JLS, MCMO, MJR, and JW are employees of and hold shares in AstraZeneca, whose company funded this study. SM is an employee of Sequenom GmbH. Patents relating to selumetinib are as follows: patentid patenttitle, US200903005, 8, tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide, MEK inhibitor useful in the treatment of cancer, US200924627, 4 pharmaceutical composition 271 US201013051, 9 combination therapy comprising azd2171 and azd6244 or mek-inhibitor. II, US200323286, 9 N3 alkylated benzimidazole derivatives as MEK inhibitors, us7842816 n3 alkylated benzimidazole derivatives as MEK inhibitors, US7777050 N3 alkylated benzimidazole derivatives as MEK inhibitors, US7576114 N3 alkylated benzimidazole derivatives as MEK inhibitors, US8193229, method of treatment using n3 alkylated benzimidazole derivatives as MEK inhibitors, US8193230, compositions comprising n3 alkylated benzimidazole derivatives as MEK inhibitors and methods of use thereof, us7235537, N3 alkylated benzimidazole derivatives as MEK inhibitors, US7973170, N3 alkylated benzimidazole derivatives as MEK inhibitors, US8003805, N3 alkylated benzimidazole derivatives as MEK inhibitors, US7425637, N3 alkylated benzimidazole derivatives as MEK inhibitors, US8178693, N3 alkylated benzimidazole derivatives as MEK inhibitors. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: JLS MCMO SM. Performed the experiments: JLS SM. Analyzed the data: JLS SM MCMO. Contributed reagents/materials/analysis tools: JLS MCMO SM. Contributed to the writing of the manuscript: JLS SM MCMO MJR JW.